Careers with BioLegacy
Current open positions (click to expand):
Job Description
Title: Business Development Manager – Preclinical Services (DMPK / Bioanalysis / Toxicology)
Location: San Diego, California
Department: Business Development
Reports to: Head of Business Operations
About BioLegacy Research
BioLegacy Research is a growing preclinical research organization specializing in DMPK, Bioanalysis, and Toxicology studies that support GLP and non-GLP drug development. We partner with biotech and pharmaceutical companies to deliver high-quality preclinical data that advance new therapeutics toward clinical success.
We are seeking a Business Development Manager with strong experience in preclinical sales, study quotation, and proposal generation. This person will understand the technical aspects of DMPK, Bioanalysis, and Toxicology services, manage client relationships, coordinate between internal scientific teams, and prepare accurate and timely sales quotes, proposals, and SOWs (Statements of Work).
Key Responsibilities
Client Engagement & Sales
- Identify, qualify, and pursue new business opportunities for preclinical services including in vitro ADME, in vivo PK/TK, GLP bioanalysis, and toxicology studies.
- Serve as the primary client contact for RFPs (Requests for Proposal) and RFQs (Requests for Quotation), ensuring timely and detailed responses.
- Prepare and manage customized proposals, quotations, pricing sheets, and contracts in collaboration with Study Directors, operations, and finance teams.
- Lead the proposal generation and cost estimation process, ensuring accuracy in technical scope, study design, and timelines.
- Support pricing strategy development, manage quote approvals, and ensure proposals align with company margin and capacity goals.
- Build and maintain long-term relationships with key biotech and pharma accounts, ensuring repeat business and client satisfaction.
- Meet or exceed annual sales and revenue targets through proactive pipeline management and strategic client engagement.
Cross-Functional Coordination
- Collaborate with DMPK, Bioanalysis, Toxicology, Operations, QA, and Finance departments to ensure client requirements are accurately translated into study plans and quotes.
- Facilitate internal discussions to align scientific feasibility, resource allocation, and pricing prior to proposal submission.
- Track project progress post-award, maintaining consistent communication between clients and internal teams.
- Support contract negotiation, study scheduling, and change order management as needed.
Technical & Strategic Expertise
- Demonstrate working knowledge of drug metabolism, pharmacokinetics, bioanalytical method development (LC-MS/MS), and toxicology study design.
- Understand GLP and regulatory requirements influencing study scope, cost, and timelines.
- Contribute scientific input to proposals, SOWs, and client presentations.
- Participate in conferences, trade shows, and client visits to represent BioLegacy’s technical capabilities.
- Collect client feedback, monitor industry trends, and support leadership in developing new service offerings.
Qualifications
Education & Experience
- Bachelor’s, Master’s, or Ph.D. in Pharmacology, Pharmaceutical Sciences, Toxicology, Chemistry, or related field.
- Minimum 3–5 years of business development, client services, or proposal management experience within a CRO, bioanalytical laboratory, or preclinical research environment.
- Proven experience with proposal generation, study quotation, cost estimation, RFP/RFQ responses, and SOW preparation.
- Hands-on or working knowledge of DMPK, Bioanalysis, and Toxicology workflows (GLP preferred).
- Demonstrated success in managing scientific client accounts and supporting IND-enabling studies.
Skills & Competencies
- Strong understanding of preclinical study design and terminology (ADME, PK, TK, LC-MS/MS, dose routes, bioanalytical validation).
- Proficiency with CRM and quotation management tools (Salesforce, HubSpot, or similar).
- Exceptional organizational and project management skills with attention to detail and deadlines.
- Ability to coordinate cross-functional teams and communicate effectively with scientists, clients, and leadership.
- Proven record of developing and presenting accurate, competitive, and timely sales quotes.
- Strong analytical and negotiation skills with a client-first mindset.
- Self-motivated and goal-oriented, with the ability to work independently in a fast-paced environment.
Why Join BioLegacy
- Be part of an expanding, science-driven organization shaping the future of preclinical development.
- Collaborate with leading scientists and clients in DMPK, Bioanalysis, and Toxicology fields.
- Competitive salary with base + commission and performance incentives.
- Opportunities for professional growth in a collaborative and innovative work environment.
Equal Opportunity Employer
BioLegacy, part of the PharmaLegacy family, is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Employment decisions are made based on qualifications, merit, and business needs without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Job Description
Title: Scientist / Senior Scientist – Bioanalytical Immunogenicity (ADA/NAb Assay Development)
Location: San Diego, CA | Full-Time
Who We Are
BioLegacy, part of the PharmaLegacy family, is a leading preclinical contract research organization (CRO) dedicated to delivering high-quality, GLP-compliant research services to support drug development. Our team of passionate scientists partners with clients across the globe to provide innovative solutions in bioanalysis, immunology, oncology, and more. We are committed to scientific excellence, regulatory integrity, and helping our partners bring life-changing therapies to patients faster.
About the Role
We are seeking a Scientist or Senior Scientist to join our Bioanalytical team, specializing in the development and validation of Anti-Drug Antibody (ADA) and Neutralizing Antibody (NAb) assays for preclinical GLP studies.
In this bench-focused role, you will design, optimize, and implement cutting-edge bioanalytical methods—leveraging platforms such as ELISA, MSD, Luminex, and cell-based assays—to evaluate immunogenicity in support of drug development programs.
Please note: This role does not involve analysis of clinical samples.
Key Responsibilities
- Develop & Validate Immunogenicity Assays – Design, optimize, and validate ADA and NAb ligand binding assays (ELISA, MSD), cell-based assays, and flow cytometry-based methods for preclinical studies.
- Ensure Regulatory Compliance – Conduct method validation in accordance with FDA, ICH, and EMA guidelines in GLP and non-GLP environments.
- Analyze & Report Data – Interpret bioanalytical results, prepare technical reports, and present findings to cross-functional teams; link immunogenicity data to PK/PD outcomes.
- Collaborate Across Functions – Partner with internal teams and CROs to ensure scientific rigor, regulatory compliance, and timely project delivery.
- Drive Innovation – Implement process improvements, evaluate emerging technologies, and support automation initiatives to enhance assay quality and throughput.
Qualifications
Required
- Ph.D. in Immunology, Biochemistry, Molecular Biology, or related field with 0–2 years of postdoctoral or industry experience; Master’s degree with 3+ years; or Bachelor’s degree with 4+ years of relevant industry experience.
- Proven hands-on experience developing and validating ADA and NAb assays.
- Proficiency with ELISA, MSD, and cell-based assays.
- Strong understanding of GLP-compliant bioanalytical workflows and method validation.
- In-depth knowledge of global regulatory expectations (FDA, ICH, EMA) for immunogenicity testing.
- Skilled in data interpretation; familiarity with analytical/statistical software.
- Excellent written and verbal communication skills; collaborative and solutions-focused mindset.
Preferred
- Experience with flow cytometry-based immunogenicity assays.
- Additional expertise in PCR, LC-MS, or other analytical platforms.
Equal Opportunity Employer
BioLegacy, part of the PharmaLegacy family, is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Employment decisions are made based on qualifications, merit, and business needs without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Job Description
Title: Scientist / Study Director – In Vivo Pharmacology, DMPK & Toxicology
Location: San Diego, California
Department: Preclinical Research
Reports to: Director of Preclinical Sciences
About BioLegacy Research
BioLegacy Research is a fast-growing preclinical research organization advancing drug discovery and development through high-quality in vivo pharmacology, DMPK, and toxicology studies. We partner with biotechnology and pharmaceutical companies to deliver reliable, GLP-compliant data that support IND-enabling and discovery programs.
About the Role
We are seeking a Scientist / Study Director with broad experience in in vivo pharmacology, drug metabolism and pharmacokinetics (DMPK), and toxicology, capable of leading complex preclinical studies across multiple animal species. The ideal candidate will have a strong record in study design, model development, data interpretation, and cross-functional coordination.
Key Responsibilities
In Vivo & Preclinical Leadership
- Design, conduct, and oversee in vivo pharmacology, PK/TK, and toxicology studies in rodents and large animals (including dogs, monkeys, rabbits, and pigs).
- Serve as Study Director or Principal Investigator for GLP and non-GLP studies, ensuring regulatory compliance, data integrity, and scientific rigor.
- Develop and refine disease models in therapeutic areas such as cardiovascular, metabolic, oncology, renal, inflammation, fibrosis, and ophthalmology.
- Execute and guide complex surgical and dosing procedures (IV, IP, SC, PO, inhalation, infusion, mini-pump implantation, and gene delivery).
- Collaborate with bioanalytical, toxicology, and formulation teams to integrate PK/PD and ADME data into study reports.
- Write study protocols, amendments, IACUC submissions, and final reports.
DMPK & Pharmacokinetic Expertise - Design studies to characterize absorption, distribution, metabolism, and excretion (ADME) profiles of test articles.
- Analyze and interpret PK/PD and exposure-response data across species to support dose selection and safety evaluation.
- Partner with bioanalytical scientists on sampling strategy, assay validation, and data review.
- Provide DMPK input for discovery, translational, and IND-enabling programs.
Toxicology & Safety Assessment - Support toxicology and safety pharmacology study design and data interpretation.
- Collaborate with toxicologists, veterinarians, and pathologists to evaluate safety, tolerability, and mechanism-related findings.
- Participate in the generation of reports for regulatory submissions and sponsor presentations.
Cross-Functional Collaboration & Client Support
- Act as the scientific liaison between sponsors and internal functional teams.
- Present data and study progress in internal meetings and client updates.
- Contribute to proposal development and study quotations, providing scientific input on scope and design.
- Mentor junior scientists and ensure high standards of technical training and animal welfare.
Qualifications
- Ph.D. or M.S. in Pharmacology, Toxicology, Pharmaceutical Sciences, or related life science.
- Minimum 5 years of experience in in vivo pharmacology, DMPK, or toxicology within a CRO, biotech, or pharmaceutical environment.
- Proven record as a Study Director or lead scientist managing multi-species preclinical studies.
- Deep understanding of cardiovascular, renal, metabolic, inflammatory, and oncology models.
- Skilled in animal handling, surgical techniques, and physiological monitoring (e.g., telemetry, echocardiography, pressure-volume loop systems).
- Familiar with GLP, IACUC, and FDA regulatory expectations for preclinical studies.
- Excellent skills in scientific writing, data interpretation, and cross-functional communication.
- Highly organized, detail-oriented, and capable of managing multiple concurrent studies.
Why Join BioLegacy Research
- Lead innovative in vivo and DMPK studies supporting translational and IND-enabling programs.
- Work across diverse therapeutic areas and animal models.
- Collaborate with experienced scientists in a growing, research-driven environment.
- Competitive compensation, performance incentives, and professional growth opportunities.
- Commitment to scientific integrity, innovation, and animal welfare.
Equal Opportunity Employer
BioLegacy, part of the PharmaLegacy family, is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Employment decisions are made based on qualifications, merit, and business needs without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Job Description
Title: Research Associate I - In Vivo Pharmacology
Location: San Diego, California
Department: Preclinical Research
About BioLegacy Research
At Biolegacy Research, we are a small, collaborative team dedicated to advancing preclinical science with precision and compassion. Our mission is to drive meaningful discovery through rigorous, humane in vivo pharmacology studies. We foster a supportive and inclusive workplace where open communication, respect, and continuous learning thrive. Here, your contributions will be valued, and you’ll have the chance to work closely with experienced scientists while growing your expertise and advancing your career.
About the Role
We are seeking a Research Associate with advanced, hands-on in vivo pharmacology experience to join our team. This role requires an individual who is already highly proficient in animal research techniques and capable of independently performing study procedures from start to finish. You will work with both small and large laboratory animals, ensuring the highest standards of scientific rigor, animal welfare, and compliance.
What You'll Do
- Independently perform complex in vivo procedures, including dosing (various routes), blood/tissue collection, necropsy, anesthesia monitoring, and post-operative care.
- Confidently handle and restrain animals (rodents, rabbits, canines, swine), ensuring welfare monitoring and adherence to IACUC-approved protocols.
- Prepare drug formulations and manage biological sample collection and processing.
- Accurately record, organize, and review experimental data with strong attention to detail.
- Maintain and calibrate lab equipment, report malfunctions promptly, and ensure lab readiness.
- Track and manage inventory of supplies to support study continuity.
- Follow GLP standards, SOPs, and strict documentation protocols.
- Contribute to study planning, data review, and analysis in collaboration with scientists.
- Work flexible hours (occasional mornings, evenings, or weekends) to support study timelines.
What You Bring
Required
- Bachelor’s degree in life sciences or related field, plus 3–5 years of direct in vivo research experience.
- Proven proficiency in animal handling, dosing, blood collection, anesthesia, necropsy, and post-surgical care across both small and large animal models.
- Demonstrated ability to independently plan and execute in vivo techniques, not solely under supervision or training.
- Strong familiarity with laboratory safety, IACUC compliance, and GLP principles.
- Excellent attention to detail, organizational skills, and precise recordkeeping.
- Effective verbal and written communication skills.
- Willingness to provide vaccination records and obtain required vaccines (e.g., tetanus, rabies) prior to employment.
Preferred
- ALAT or LAT certification (AALAS).
- Preclinical industry experience with multiple species.
- Familiarity with advanced pharmacology models or surgical techniques.
Why Join Us
- Direct training in advanced in vivo pharmacology techniques.
- Support for AALAS certification and career development.
- A collaborative, mission-driven team environment where your skills and contributions matter.
Why Join BioLegacy Research
- Lead innovative in vivo and DMPK studies supporting translational and IND-enabling programs.
- Work across diverse therapeutic areas and animal models.
- Collaborate with experienced scientists in a growing, research-driven environment.
- Competitive compensation, performance incentives, and professional growth opportunities.
- Commitment to scientific integrity, innovation, and animal welfare.
Equal Opportunity Employer
BioLegacy, part of the PharmaLegacy family, is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Employment decisions are made based on qualifications, merit, and business needs without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.