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title: "Metabolism"
canonical: "https://biolegacyresearch.com/therapeutic-areas/metabolism-studies/"
lastmod: "2026-01-28T01:54:25+00:00"
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---

Preclinical Metabolism Studies

BioLegacy’s areas of expertise include:

Diabetes

Obesity

Diabetes

Preclinical evaluation of novel anti-diabetic agents requires translatable models that accurately recapitulate the distinct pathophysiologies of hyperglycemia and insulin resistance. BioLegacy utilizes a comprehensive, multi-species platform of well-characterized Type 1 and Type 2 diabetes models. Integrating these gold-standard genetic and induced models with pivotal functional tests of glucose homeostasis, we deliver clear, quantitative data on glycemic control and insulin sensitivity essential for advancing your diabetes therapeutic.

Type 1 & 2 Models (Mouse, Rat, Minipig):

Multi-species assessments in both autoimmune-driven (T1D) and metabolic (T2D) disease contexts.

Diet-Induced Type 2 Diabetes:

High-fat diet with streptozotocin induces a clinically relevant state of obesity, insulin resistance, and hyperglycemia.

Genetic Models (Mouse, Rat):

Spontaneous genetic models (e.g., Zucker rats) that recapitulate the pathophysiology of metabolic syndrome.

db/db Mouse Models:

The gold-standard monogenic model of severe Type 2 diabetes, driven by leptin receptor deficiency.

Oral Glucose Tolerance Test (OGTT):

A critical functional assay to assess a therapeutic's impact on glucose disposal following an oral glucose challenge.

Insulin Tolerance Tests (IP & IV):

A key in vivo test to quantitatively measure a compound's effect on peripheral insulin sensitivity.

Diabetic Models in Pigs:

A highly translatable large animal model for studying diabetic complications and testing medical devices in a diabetic setting.

Start Your Diabetes Study

Obesity

BioLegacy’s evaluation of anti-obesity therapeutics extend beyond simple body weight measurement to nuanced characterizations of their effect on body composition and energy expenditure. We use both diet-induced and genetic models of obesity to provide these holistic assessments. Integrating gold-standard in vivo systems with precise, quantitative bioanalytical readouts, we deliver a clear, mechanistic profile of your compound’s ability to reduce adiposity, preserve lean mass, and favorably alter metabolic parameters.

Diet-Induced Obesity:

The gold-standard translational model using high-fat diets to induce a polygenic obesity phenotype that closely mimics the human condition.

Genetic Models of Obesity (Mouse & Rat):

Expertise in leveraging monogenic models (e.g., ob/ob, db/db, Zucker rats) with severe, early-onset obesity for robust mechanistic and efficacy studies.

Start Your Obesity Study

Don’t see a model you need? Our portfolio of validated models expands all the time. Ask us - we might have it!

Tip the scales in favor of your IND submission.

Study design support
Small & large animal studies
IND-enabling GLP studies
Optional SEND datasets
Rapid study initiation - usually in under 2 weeks

BioLegacy delivers the data you need. Contact us!

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